InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thbd

Summary

InnateDB Protein

IDBP-208964.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thbd

Protein Name

thrombomodulin

Synonyms

AI385582; CD141; TM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096877

InnateDB Gene

IDBG-208962 (Thbd)

Protein Structure

UniProt Annotation

Function

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Endothelial cells are unique in synthesizing thrombomodulin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007165	signal transduction
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0010165	response to X-ray
GO:0032496	response to lipopolysaccharide
GO:0050819	negative regulation of coagulation
GO:0051591	response to cAMP

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:98736

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001491 Thrombomodulin
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR015149 Thrombomodulin-like, EGF-like
IPR016187 C-type lectin fold
IPR016316 Complement component C1q/Thrombomodulin

PFAM

PF00008
PF00059
PF07645
PF09064

PRINTS

PR00907

PIRSF

PIRSF001775

SMART

SM00181
SM00034
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References