InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gzf1

Summary

InnateDB Protein

IDBP-209006.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gzf1

Protein Name

GDNF-inducible zinc finger protein 1

Synonyms

8430437G08Rik; mGZF1; Zfp336;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028928

InnateDB Gene

IDBG-209004 (Gzf1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14522971}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:14522971}. Note=Predominantly nuclear.

Disease Associations

Tissue Specificity

Expressed in several tissues, with highest levels in liver. Also expressed in embryos from 7 to 17 dpc. {ECO:0000269PubMed:14522971}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001206	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated