InnateDB Protein
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IDBP-209012.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rbbp6
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Protein Name
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retinoblastoma binding protein 6
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Synonyms
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4933422O15Rik; AI316869; BB233631; C030034J04Rik; C77662; P2P-R; PACT;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000095670
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InnateDB Gene
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IDBG-209019 (Rbbp6)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation. {ECO:0000250, ECO:0000269PubMed:17470788}.
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Subcellular Localization |
Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with mitotic chromosomes. Co- localizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. Expressed at lower levels in brain, heart, kidney, liver, lung, skeletal muscle, spleen, thymus and tongue. {ECO:0000269PubMed:9010216, ECO:0000269PubMed:9037032}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
44 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:894835
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InterPro |
IPR014891
DWNN domain
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PFAM |
PF08783
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P97868
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PhosphoSite |
PhosphoSite-P97868
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TrEMBL |
D3YZU8
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UniProt Splice Variant |
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Entrez Gene |
19647
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UniGene |
Mm.4480
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RefSeq |
NP_778188
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MGI ID |
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MGI Symbol |
Rbbp6
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OMIM |
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CCDS |
CCDS21817
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HPRD |
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IMGT |
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EMBL |
AC125221
AK045635
AK079129
AK081261
AK144758
AK160656
AK161231
BC025874
U28789
U83913
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GenPept |
AAB49620
AAC72432
AAH25874
BAC32441
BAC37553
BAC38179
BAE26051
BAE35944
BAE36255
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