InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdx2

Summary

InnateDB Protein

IDBP-209015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdx2

Protein Name

caudal type homeobox 2

Synonyms

Cdx-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031650

InnateDB Gene

IDBG-209013 (Cdx2)

Protein Structure

UniProt Annotation

Function

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Intestine; expressed specifically in gut epithelium where it is not restricted to a particular cell lineage. Abundant expression is seen in the proximal colon with slightly lower levels in distal colon. Expression in the proximal colon is not restricted either to a particular cell lineage or stage of differentiation while in the distal colon it is more abundant in the differentiated cells towards the top of the crypt.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	7 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001824	blastocyst development
GO:0001829	trophectodermal cell differentiation
GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0007389	pattern specification process
GO:0008284	positive regulation of cell proliferation
GO:0008333	endosome to lysosome transport
GO:0009952	anterior/posterior pattern specification
GO:0030154	cell differentiation
GO:0035019	somatic stem cell maintenance
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045597	positive regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060711	labyrinthine layer development

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0017053	transcriptional repressor complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:88361

InterPro

IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR006820 Caudal-like activation domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF04731

PRINTS

PR00031
PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt