InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbbp6

Summary

InnateDB Protein

IDBP-209021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbbp6

Protein Name

retinoblastoma binding protein 6

Synonyms

4933422O15Rik; AI316869; BB233631; C030034J04Rik; C77662; P2P-R; PACT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071519

InnateDB Gene

IDBG-209019 (Rbbp6)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation. {ECO:0000250, ECO:0000269PubMed:17470788}.

Subcellular Localization

Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with mitotic chromosomes. Co- localizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis. Expressed at lower levels in brain, heart, kidney, liver, lung, skeletal muscle, spleen, thymus and tongue. {ECO:0000269PubMed:9010216, ECO:0000269PubMed:9037032}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0016567	protein ubiquitination
GO:0035264	multicellular organism growth
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048568	embryonic organ development
GO:0061053	somite development