Mus musculus Protein: Pan3 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Protein | IDBP-209070.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Pan3 | ||||||||||||||
Protein Name | PAN3 polyA specific ribonuclease subunit homolog (S. cerevisiae) | ||||||||||||||
Synonyms | 2700050F09Rik; A430027N15Rik; AU014670; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000031651 | ||||||||||||||
InnateDB Gene | IDBG-209068 (Pan3) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255HAMAP-Rule:MF_03181}. | ||||||||||||||
Subcellular Localization | Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03181, ECO:0000269PubMed:18625844}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:1919837 | ||||||||||||||
InterPro |
IPR000571
Zinc finger, CCCH-type IPR000719 Protein kinase domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain |
||||||||||||||
PFAM |
PF00642
PF00069 |
||||||||||||||
PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00356
SM00220 |
||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q640Q5 | ||||||||||||||
PhosphoSite | PhosphoSite-Q640Q5 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 72587 | ||||||||||||||
UniGene | Mm.489723 | ||||||||||||||
RefSeq | NP_082567 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Pan3 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS39401 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AC131730 AC134441 AK012409 AK028869 AK153632 BC082547 | ||||||||||||||
GenPept | AAH82547 BAB28221 BAC26161 BAE32127 | ||||||||||||||