InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eme1

Summary

InnateDB Protein

IDBP-209150.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eme1

Protein Name

essential meiotic endonuclease 1 homolog 1 (S. pombe)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036361

InnateDB Gene

IDBG-209148 (Eme1)

Protein Structure

UniProt Annotation

Function

Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269PubMed:14609959}.

Subcellular Localization

Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Weakly expressed in brain, heart, kidney, liver, lung, muscle, skin, small intestine, spleen, stomach, testis and thymus. Also expressed in embryonic stem cells (ES cells). {ECO:0000269PubMed:14609959}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0072429	response to intra-S DNA damage checkpoint signaling
GO:0090305	nucleic acid phosphodiester bond hydrolysis