Version 5.4
Mus musculus Protein: Mtus2
Summary
InnateDB Protein IDBP-209193.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtus2
Protein Name microtubule associated tumor suppressor candidate 2
Synonyms 5730592G18Rik; A730013O20Rik; AU067634; C130038G02Rik; Cazip; Gm763; mKIAA0774;
Species Mus musculus
Ensembl Protein ENSMUSP00000082694
InnateDB Gene IDBG-209191 (Mtus2)
Protein Structure
UniProt Annotation
Function Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus- end) of microtubules. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart from early embryonic development onwards. Later during embryonic development, expressed in brain and nervous system, in limb buds and in the epithelium lining the bronchia of the lung. Detected in adult brain, heart and eye, but not detected in other adult tissues examined. {ECO:0000269PubMed:19806667}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042803 protein homodimerization activity
Biological Process
Cellular Component
GO:0005813 centrosome
GO:0005881 cytoplasmic microtubule
Protein Structure and Domains
PDB ID MGI:1915388
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UHD3
PhosphoSite PhosphoSite-Q3UHD3
TrEMBL D3YZ59
UniProt Splice Variant
Entrez Gene 77521
UniGene Mm.407843
RefSeq NP_084196
MGI ID
MGI Symbol Mtus2
OMIM
CCDS CCDS19881
HPRD
IMGT
EMBL AB093263 AC109498 AC117725 AC133954 AC158301 AK019985 AK147457 BC055016 BC150942
GenPept AAH55016 AAI50943 BAB31952 BAC41447 BAE27924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca