InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plxna2

Summary

InnateDB Protein

IDBP-209286.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxna2

Protein Name

plexin A2

Synonyms

2810428A13Rik; AA589422; AW457381; mKIAA0463; OCT; PlexA2; Plxn2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027952

InnateDB Gene

IDBG-209284 (Plxna2)

Protein Structure

UniProt Annotation

Function

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. {ECO:0000269PubMed:10520994, ECO:0000269PubMed:10781943, ECO:0000269PubMed:20877282}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20877282, ECO:0000269PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269PubMed:20877282, ECO:0000269PubMed:20881961}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity

Biological Process

GO:0001756	somitogenesis
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0021915	neural tube development
GO:0021935	cerebellar granule cell precursor tangential migration
GO:0030334	regulation of cell migration
GO:0051642	centrosome localization
GO:0060037	pharyngeal system development
GO:0060174	limb bud formation
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:107684

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70207