Version 5.4
Mus musculus Protein: Cst7
Summary
InnateDB Protein IDBP-209297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cst7
Protein Name cystatin F (leukocystatin)
Synonyms Cmap;
Species Mus musculus
Ensembl Protein ENSMUSP00000086606
InnateDB Gene IDBG-209295 (Cst7)
Protein Structure
UniProt Annotation
Function Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:1298217
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O89098
PhosphoSite PhosphoSite-
TrEMBL Q9QWL5
UniProt Splice Variant
Entrez Gene 13011
UniGene
RefSeq NP_034107
MGI ID
MGI Symbol Cst7
OMIM
CCDS CCDS16857
HPRD
IMGT
EMBL AB015224 AF031825 AF031826 AK004420 AK170583 BC117047 BC117049 CH466519
GenPept AAC40139 AAC40140 AAI17048 AAI17050 BAA34940 BAB23298 BAE41893 EDL28568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca