InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Katnal1

Summary

InnateDB Protein

IDBP-209305.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Katnal1

Protein Name

katanin p60 subunit A-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043210

InnateDB Gene

IDBG-209303 (Katnal1)

Protein Structure

UniProt Annotation

Function

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. {ECO:0000269PubMed:22654668}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000255HAMAP- Rule:MF_03024, ECO:0000269PubMed:22654668}. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells.

Disease Associations

Tissue Specificity

Widely expressed, including in testis, brain, heart, lung, kidney, liver, spleen, seminal vesicles and ovary. In testis, restricted to Sertoli cells within the seminiferous epithelium (at protein level). {ECO:0000269PubMed:22654668}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008568	microtubule-severing ATPase activity
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007283	spermatogenesis
GO:0051013	microtubule severing

Cellular Component

GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:2387638

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR007330 MIT
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR015415 Vps4 oligomerisation, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF04212
PF05496
PF09336

PRINTS

PIRSF

SMART

SM00382
SM00745

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K0T4