Version 5.4
Mus musculus Protein: Gtf3c1
Summary
InnateDB Protein IDBP-209322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf3c1
Protein Name general transcription factor III C 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000056719
InnateDB Gene IDBG-209320 (Gtf3c1)
Protein Structure
UniProt Annotation
Function Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0000127 transcription factor TFIIIC complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:107887
InterPro IPR007309 B-block binding subunit of TFIIIC
PFAM PF04182
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K284
PhosphoSite PhosphoSite-Q8K284
TrEMBL Q3UY03
UniProt Splice Variant
Entrez Gene 233863
UniGene Mm.294173
RefSeq NP_997122
MGI ID
MGI Symbol Gtf3c1
OMIM
CCDS CCDS40122
HPRD
IMGT
EMBL AK038537 AK135072 AK142715 AK143008 BC004708 BC032208 BC067041
GenPept AAH04708 AAH32208 AAH67041 BAC30032 BAE22410 BAE25173 BAE25245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca