InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cr1l

Summary

InnateDB Protein

IDBP-209352.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cr1l

Protein Name

complement component (3b/4b) receptor 1-like

Synonyms

Crry; Mcp; mCRY;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074902

InnateDB Gene

IDBG-209348 (Cr1l)

Protein Structure

UniProt Annotation

Function

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion. {ECO:0000269PubMed:10642554, ECO:0000269PubMed:10779754, ECO:0000269PubMed:11986227, ECO:0000269PubMed:1730912, ECO:0000269PubMed:7528766}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Ubiquitously expressed (at protein level). {ECO:0000269PubMed:2911011, ECO:0000269PubMed:7691944}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001701	in utero embryonic development
GO:0006958	complement activation, classical pathway
GO:0007565	female pregnancy
GO:0030449	regulation of complement activation
GO:0045087	innate immune response
GO:0045916	negative regulation of complement activation