InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r9b

Summary

InnateDB Protein

IDBP-209377.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r9b

Protein Name

protein phosphatase 1, regulatory subunit 9B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041732

InnateDB Gene

IDBG-209375 (Ppp1r9b)

Protein Structure

UniProt Annotation

Function

Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha- adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse. Cell junction, adherens junction {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Enriched at synapse and cadherin- based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines. Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0007015	actin filament organization
GO:0016358	dendrite development
GO:0016477	cell migration
GO:0019722	calcium-mediated signaling
GO:0030036	actin cytoskeleton organization
GO:0030308	negative regulation of cell growth
GO:0046847	filopodium assembly
GO:0071315	cellular response to morphine
GO:2000474	regulation of opioid receptor signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030864	cortical actin cytoskeleton
GO:0032587	ruffle membrane
GO:0043197	dendritic spine
GO:0045202	synapse