InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alox5ap

Summary

InnateDB Protein

IDBP-209380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox5ap

Protein Name

arachidonate 5-lipoxygenase activating protein

Synonyms

Flap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071130

InnateDB Gene

IDBG-209378 (Alox5ap)

Protein Structure

UniProt Annotation

Function

Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). unstructured (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000269PubMed:19075240}; Multi-pass membrane protein {ECO:0000269PubMed:19075240}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0050544	arachidonic acid binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0002675	positive regulation of acute inflammatory response
GO:0019370	leukotriene biosynthetic process
GO:0043085	positive regulation of catalytic activity
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane