InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lat

Summary

InnateDB Protein

IDBP-209438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lat

Protein Name

linker for activation of T cells

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032997

InnateDB Gene

IDBG-209436 (Lat)

Protein Structure

UniProt Annotation

Function

Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269PubMed:10843385}.

Subcellular Localization

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.

Disease Associations

Tissue Specificity

Expressed in T-cells and mast cells. {ECO:0000269PubMed:10843385}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007265	Ras protein signal transduction
GO:0009967	positive regulation of signal transduction
GO:0010467	gene expression
GO:0019722	calcium-mediated signaling
GO:0035556	intracellular signal transduction
GO:0043303	mast cell degranulation
GO:0048872	homeostasis of number of cells
GO:0050863	regulation of T cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0016021	integral component of membrane
GO:0042629	mast cell granule