InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsph1

Summary

InnateDB Protein

IDBP-209446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsph1

Protein Name

heat shock 105kDa/110kDa protein 1

Synonyms

105kDa; AI790491; hsp-E7I; Hsp105; Hsp110;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074392

InnateDB Gene

IDBG-209442 (Hsph1)

Protein Structure

UniProt Annotation

Function

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. {ECO:0000269PubMed:14644449, ECO:0000269PubMed:15292236}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10865058}. Nucleus {ECO:0000269PubMed:10865058}. Note=Strictly cytoplasmic in neurons.

Disease Associations

Tissue Specificity

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Within the brain, expression is restricted to neurons (at protein level). Overexpressed in cancer cells. {ECO:0000269PubMed:10865058, ECO:0000269PubMed:16232202}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006986	response to unfolded protein
GO:0043524	negative regulation of neuron apoptotic process
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051135	positive regulation of NK T cell activation
GO:0070507	regulation of microtubule cytoskeleton organization

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:105053

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61699