Version 5.4
Mus musculus Protein: Nfatc2ip
Summary
InnateDB Protein IDBP-209460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfatc2ip
Protein Name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
Synonyms D7Ertd304e; NIP45;
Species Mus musculus
Ensembl Protein ENSMUSP00000075094
InnateDB Gene IDBG-209458 (Nfatc2ip)
Protein Structure
UniProt Annotation
Function In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'- methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down- regulates formation of poly-SUMO chains by UBE2I/UBC9. {ECO:0000269PubMed:20077568, ECO:0000269PubMed:20133688}.
Subcellular Localization Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
Disease Associations
Tissue Specificity Highest level detected in spleen, thymus and testis. {ECO:0000269PubMed:8943202}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001816 cytokine production
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1329015
InterPro IPR000626 Ubiquitin-like
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain
PFAM PF00240
PF14560
PF11976
PRINTS
PIRSF
SMART SM00213
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O09130
PhosphoSite PhosphoSite-O09130
TrEMBL
UniProt Splice Variant
Entrez Gene 18020
UniGene Mm.1389
RefSeq NP_035030
MGI ID 3A4S
MGI Symbol Nfatc2ip
OMIM
CCDS CCDS21827
HPRD
IMGT
EMBL AK005947 AK030107 BC113761 U76759
GenPept AAC52963 AAI13762 BAB24331 BAC26788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca