Version 5.4
Mus musculus Protein: Nsfl1c
Summary
InnateDB Protein IDBP-209487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nsfl1c
Protein Name NSFL1 (p97) cofactor (p47)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000086542
InnateDB Gene IDBG-209481 (Nsfl1c)
Protein Structure
UniProt Annotation
Function Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Chromosome {ECO:0000250}. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID MGI:3042273
InterPro IPR001012 UBX domain
IPR009060 UBA-like
IPR012989 SEP domain
IPR029071 Ubiquitin-related domain
PFAM PF00789
PF08059
PRINTS
PIRSF
SMART SM00166
SM00553
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CZ44
PhosphoSite PhosphoSite-Q9CZ44
TrEMBL Q3UVN5
UniProt Splice Variant
Entrez Gene 386649
UniGene Mm.419479
RefSeq NP_938085
MGI ID
MGI Symbol Nsfl1c
OMIM
CCDS CCDS16868
HPRD
IMGT
EMBL AK013024 AK039136 AK137088 AL928719 BC050936
GenPept AAH50936 BAB28604 BAC30250 BAE23234 CAM23816

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca