InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp2a1

Summary

InnateDB Protein

IDBP-209501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2a1

Protein Name

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

Synonyms

SERCA1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032974

InnateDB Gene

IDBG-209499 (Atp2a1)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006937	regulation of muscle contraction
GO:0006942	regulation of striated muscle contraction
GO:0008637	apoptotic mitochondrial changes
GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0034976	response to endoplasmic reticulum stress
GO:0045988	negative regulation of striated muscle contraction
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0051659	maintenance of mitochondrion location
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0090076	relaxation of skeletal muscle

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031673	H zone
GO:0031674	I band
GO:0033017	sarcoplasmic reticulum membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:105058

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt