InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rad21l

Summary

InnateDB Protein

IDBP-209552.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad21l

Protein Name

RAD21-like (S. pombe)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094174

InnateDB Gene

IDBG-209550 (Rad21l)

Protein Structure

UniProt Annotation

Function

Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I. Not required for meiosis in females in young mice, while it is required later as mice age. {ECO:0000269PubMed:21242291, ECO:0000269PubMed:21274006, ECO:0000269PubMed:21527826, ECO:0000269PubMed:21743440, ECO:0000269PubMed:22711701}.

Subcellular Localization

Nucleus. Chromosome. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements.

Disease Associations

Tissue Specificity

Specifically expressed in male and female gonads (at protein level). {ECO:0000269PubMed:21242291, ECO:0000269PubMed:21274006, ECO:0000269PubMed:21527826}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006302	double-strand break repair
GO:0007129	synapsis
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0030999	linear element assembly
GO:0070197	attachment of telomeric heterochromatin to nuclear envelope
GO:0072520	seminiferous tubule development