InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cln3

Summary

InnateDB Protein

IDBP-209630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cln3

Protein Name

ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)

Synonyms

AI323623;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081636

InnateDB Gene

IDBG-209626 (Cln3)

Protein Structure

UniProt Annotation

Function

Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000046	autophagic vacuole fusion
GO:0001508	action potential
GO:0001575	globoside metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0006672	ceramide metabolic process
GO:0006678	glucosylceramide metabolic process
GO:0006681	galactosylceramide metabolic process
GO:0006684	sphingomyelin metabolic process
GO:0006865	amino acid transport
GO:0006898	receptor-mediated endocytosis
GO:0007034	vacuolar transport
GO:0007040	lysosome organization
GO:0007042	lysosomal lumen acidification
GO:0008306	associative learning
GO:0010468	regulation of gene expression
GO:0015809	arginine transport
GO:0016236	macroautophagy
GO:0016242	negative regulation of macroautophagy
GO:0016485	protein processing
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035752	lysosomal lumen pH elevation
GO:0042133	neurotransmitter metabolic process
GO:0042987	amyloid precursor protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045861	negative regulation of proteolysis
GO:0047496	vesicle transport along microtubule
GO:0050885	neuromuscular process controlling balance
GO:0051480	cytosolic calcium ion homeostasis
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005776	autophagic vacuole
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0031301	integral component of organelle membrane
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:107537

InterPro

IPR003492 Batten\'s disease protein Cln3
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR018460 Batten\'s disease protein Cln3, subgroup

PFAM

PF02487

PRINTS

PR01315

PIRSF

PIRSF015974

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt