InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbc1d20

Summary

InnateDB Protein

IDBP-209646.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbc1d20

Protein Name

TBC1 domain family, member 20

Synonyms

1110028I04Rik; 2810442O16Rik; AI414693;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028963

InnateDB Gene

IDBG-209644 (Tbc1d20)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Note=Defects in Tbc1d20 are the cause of spontaneous autosomal recessive blind sterile (bs) phenotype. Bs animals exhibit embryonic non-progressive nuclear cataracts and spermatid abnormalities associated with male infertility.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0001675	acrosome assembly
GO:0002088	lens development in camera-type eye
GO:0007030	Golgi organization
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0034389	lipid particle organization
GO:0043010	camera-type eye development
GO:0070309	lens fiber cell morphogenesis
GO:0072520	seminiferous tubule development