InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phospho1

Summary

InnateDB Protein

IDBP-209658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phospho1

Protein Name

phosphatase, orphan 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057858

InnateDB Gene

IDBG-209656 (Phospho1)

Protein Structure

UniProt Annotation

Function

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. {ECO:0000269PubMed:17227223}.

Subcellular Localization

Disease Associations

Tissue Specificity

Has a 120-fold higher level of expression in bone compared with a range of soft tissues. {ECO:0000269PubMed:17227223}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016462	pyrophosphatase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding
GO:0052731	phosphocholine phosphatase activity
GO:0052732	phosphoethanolamine phosphatase activity

Biological Process

GO:0001958	endochondral ossification
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0030500	regulation of bone mineralization
GO:0035630	bone mineralization involved in bone maturation

Cellular Component

GO:0031012	extracellular matrix
GO:0065010	extracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:2447348

InterPro

IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like
IPR006384 Pyridoxal phosphate phosphatase-related
IPR016965 Phosphatase PHOSPHO-type
IPR023214 HAD-like domain

PFAM

PF06888
PF00702
PF08282
PF13419

PRINTS

PIRSF

PIRSF031051

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R2H9