InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kl

Summary

InnateDB Protein

IDBP-209672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

klotho

Synonyms

alpha-kl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077899

InnateDB Gene

IDBG-209670 (Kl)

Protein Structure

UniProt Annotation

Function

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide.Isoform 2: Secreted.Klotho peptide: Secreted.

Disease Associations

Tissue Specificity

Membrane-bound protein is present in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Soluble peptide is present in serum (100 pM) and cerebrospinal fluid. Expressed strongly in kidney, moderately in brain choroid plexus, and at low levels in pituitary, placenta, skeletal muscle, urinary bladder, aorta, pancreas, testis, ovary, colon, thyroid gland and adipocytes. {ECO:0000269PubMed:10631108, ECO:0000269PubMed:11411791, ECO:0000269PubMed:12204354, ECO:0000269PubMed:15135068, ECO:0000269PubMed:15665504, ECO:0000269PubMed:16123266, ECO:0000269PubMed:9363890, ECO:0000269PubMed:9537505}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004566	beta-glucuronidase activity
GO:0004871	signal transducer activity
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0002526	acute inflammatory response
GO:0005975	carbohydrate metabolic process
GO:0006112	energy reserve metabolic process
GO:0007568	aging
GO:0008286	insulin receptor signaling pathway
GO:0030501	positive regulation of bone mineralization
GO:0055074	calcium ion homeostasis
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome