InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trib3

Summary

InnateDB Protein

IDBP-209678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trib3

Protein Name

tribbles homolog 3 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041747

InnateDB Gene

IDBG-209676 (Trib3)

Protein Structure

UniProt Annotation

Function

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity). Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000250, ECO:0000269PubMed:12749859, ECO:0000269PubMed:12791994, ECO:0000269PubMed:22977230}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12749859, ECO:0000269PubMed:22977230}.

Disease Associations

Tissue Specificity

Highly expressed in liver. Not detected in heart, brain, spleen, lung, skeletal muscle, kidney or testis. {ECO:0000269PubMed:12749859}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0055106	ubiquitin-protein ligase regulator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0010827	regulation of glucose transport
GO:0032092	positive regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869	cellular response to insulin stimulus
GO:0034976	response to endoplasmic reticulum stress
GO:0043405	regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045599	negative regulation of fat cell differentiation
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045732	positive regulation of protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1345675

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt