InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nupr1

Summary

InnateDB Protein

IDBP-209685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nupr1

Protein Name

nuclear protein 1

Synonyms

2310032H04Rik; Com1; p8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032961

InnateDB Gene

IDBG-209683 (Nupr1)

Protein Structure

UniProt Annotation

Function

Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac) (By similarity). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3 (By similarity). NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to toxic agents, such as doxorubicin (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. {ECO:0000250, ECO:0000269PubMed:22565310}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0002526	acute inflammatory response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0006473	protein acetylation
GO:0008584	male gonad development
GO:0009636	response to toxic substance
GO:0016049	cell growth
GO:0031401	positive regulation of protein modification process
GO:0035914	skeletal muscle cell differentiation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065	positive regulation of apoptotic process
GO:0045786	negative regulation of cell cycle
GO:0048147	negative regulation of fibroblast proliferation
GO:2000194	regulation of female gonad development