InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNG3

Summary

InnateDB Protein

IDBP-20979.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNG3

Protein Name

calcium channel, voltage-dependent, gamma subunit 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000005284

InnateDB Gene

IDBG-20977 (CACNG3)

Protein Structure

UniProt Annotation

Function

Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity

Biological Process

GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0070588	calcium ion transmembrane transport
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016021	integral component of membrane
GO:0030666	endocytic vesicle membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex