InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snf8

Summary

InnateDB Protein

IDBP-209795.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snf8

Protein Name

SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)

Synonyms

D11Moh34;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006217

InnateDB Gene

IDBG-209793 (Snf8)

Protein Structure

UniProt Annotation

Function

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}. Nucleus {ECO:0000305}. Late endosome membrane {ECO:0000250}. Note=Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0015031	protein transport

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1343161

InterPro

IPR007286 EAP30
IPR016689 ESCRT-2 complex, Snf8

PFAM

PF04157

PRINTS

PIRSF

PIRSF017215

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CZ28

PhosphoSite

PhosphoSite-Q9CZ28

TrEMBL

UniProt Splice Variant

Entrez Gene

27681

UniGene

Mm.460787

RefSeq

NP_291046

MGI ID

MGI Symbol

Snf8

OMIM

CCDS

CCDS25288

HPRD

IMGT

EMBL

AK013058 AL603682 BC003938

GenPept

AAH03938 BAB28626 CAM18269