InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbx6

Summary

InnateDB Protein

IDBP-209829.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbx6

Protein Name

T-box 6

Synonyms

rv;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091579

InnateDB Gene

IDBG-209827 (Tbx6)

Protein Structure

UniProt Annotation

Function

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia. {ECO:0000269PubMed:15545628, ECO:0000269PubMed:18575602, ECO:0000269PubMed:21331042, ECO:0000269PubMed:9490412}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001707	mesoderm formation
GO:0001708	cell fate specification
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010977	negative regulation of neuron projection development
GO:0014043	negative regulation of neuron maturation
GO:0023019	signal transduction involved in regulation of gene expression
GO:0032525	somite rostral/caudal axis specification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter