InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hoxb13

Summary

InnateDB Protein

IDBP-209852.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxb13

Protein Name

homeobox B13

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056315

InnateDB Gene

IDBG-209850 (Hoxb13)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001525	angiogenesis
GO:0002009	morphogenesis of an epithelium
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0033574	response to testosterone
GO:0040008	regulation of growth
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development