InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fam57b

Summary

InnateDB Protein

IDBP-209861.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fam57b

Protein Name

family with sequence similarity 57, member B

Synonyms

1500016O10Rik; A330104J06Rik; AI413816; AW060769;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078392

InnateDB Gene

IDBG-209859 (Fam57b)

Protein Structure

UniProt Annotation

Function

Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis. {ECO:0000269PubMed:23275342}.

Subcellular Localization

Isoform 1: Golgi apparatus membrane; Multi- pass membrane protein.Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.Isoform 3: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Each isoform has a distinct expression pattern. Isoform 1 is highly expressed in brain. Isoform 2 is expressed at low levels, if any, in all analyzed tissues, with slightly higher levels in testis. Isoform 3 is expressed at very high levels in testis and, at lower levels, in white adipose tissue. In epididymal fat, isoform 3 is expressed at higher levels in obese mice compared with lean mice. By contrast, isoform 1 and 2 levels are significantly lower in obese mice compared with lean mice. {ECO:0000269PubMed:23275342}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0050291	sphingosine N-acyltransferase activity

Biological Process

GO:0045599	negative regulation of fat cell differentiation
GO:0046513	ceramide biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane