InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hoxb2

Summary

InnateDB Protein

IDBP-209922.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxb2

Protein Name

homeobox B2

Synonyms

AI894218; Hox-2.8; Hoxbes2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098092

InnateDB Gene

IDBG-209920 (Hoxb2)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0021569	rhombomere 3 development
GO:0021570	rhombomere 4 development
GO:0021612	facial nerve structural organization
GO:0048704	embryonic skeletal system morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0048857	neural nucleus development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:96183

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa

PFAM

PF00046

PRINTS

PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P0C1T1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

103889

UniGene

RefSeq

NP_598793

MGI ID

MGI Symbol

Hoxb2

OMIM

CCDS

CCDS36290

HPRD

IMGT

EMBL

AL606824 BC138494 BC138495

GenPept

AAI38495 AAI38496 CAM27581