InnateDB Protein
|
IDBP-209965.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Kctd13
|
Protein Name
|
potassium channel tetramerisation domain containing 13
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000032924
|
InnateDB Gene
|
IDBG-209963 (Kctd13)
|
Protein Structure
|
|
Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
16 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1923739
|
InterPro |
IPR000210
BTB/POZ-like
IPR003131
Potassium channel tetramerisation-type BTB domain
IPR011333
BTB/POZ fold
|
PFAM |
PF02214
|
PRINTS |
|
PIRSF |
|
SMART |
SM00225
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BGV7
|
PhosphoSite |
PhosphoSite-Q8BGV7
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
233877
|
UniGene |
Mm.245897
|
RefSeq |
NP_766335
|
MGI ID |
|
MGI Symbol |
Kctd13
|
OMIM |
|
CCDS |
CCDS21851
|
HPRD |
|
IMGT |
|
EMBL |
AF534881
AK075722
BC079607
|
GenPept |
AAH79607
AAO16177
BAC35910
|
|
|