Version 5.4
Mus musculus Protein: Cdipt
Summary
InnateDB Protein IDBP-209996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdipt
Protein Name CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
Synonyms 9530042F15Rik; D7Bwg0575e; Pis; Pis1;
Species Mus musculus
Ensembl Protein ENSMUSP00000032920
InnateDB Gene IDBG-209994 (Cdipt)
Protein Structure
UniProt Annotation
Function Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0019992 diacylglycerol binding
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0043178 alcohol binding
Biological Process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0046341 CDP-diacylglycerol metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:105491
InterPro IPR000462 CDP-alcohol phosphatidyltransferase
IPR014387 CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote
PFAM PF01066
PRINTS
PIRSF PIRSF000848
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VDP6
PhosphoSite PhosphoSite-Q8VDP6
TrEMBL
UniProt Splice Variant
Entrez Gene 52858
UniGene Mm.28219
RefSeq NP_080914
MGI ID
MGI Symbol Cdipt
OMIM
CCDS CCDS21853
HPRD
IMGT
EMBL AK076974 AK079226 AK089109 BC021473 BC024413
GenPept AAH21473 AAH24413 BAC36542 BAC37580 BAC40756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca