InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Copz2

Summary

InnateDB Protein

IDBP-210030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Copz2

Protein Name

coatomer protein complex, subunit zeta 2

Synonyms

1110012D12Rik; zeta2-COP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018816

InnateDB Gene

IDBG-210028 (Copz2)

Protein Structure

UniProt Annotation

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:17360540}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000269PubMed:17360540}; Peripheral membrane protein {ECO:0000269PubMed:17360540}; Cytoplasmic side {ECO:0000269PubMed:17360540}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006810	transport
GO:0008150	biological_process
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005829	cytosol
GO:0030137	COPI-coated vesicle
GO:0030663	COPI-coated vesicle membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane