InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dctpp1

Summary

InnateDB Protein

IDBP-210120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dctpp1

Protein Name

dCTP pyrophosphatase 1

Synonyms

2410015N17Rik; AI854235; RS21-C6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047845

InnateDB Gene

IDBG-210118 (Dctpp1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases. {ECO:0000269PubMed:17320107, ECO:0000269PubMed:19220460}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19220460}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in heart, liver, skeletal muscle, cerebellum, brain, and salivary gland. {ECO:0000269PubMed:19220460}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0016462	pyrophosphatase activity
GO:0032556	pyrimidine deoxyribonucleotide binding
GO:0047429	nucleoside-triphosphate diphosphatase activity
GO:0047840	dCTP diphosphatase activity