InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbx21

Summary

InnateDB Protein

IDBP-210155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbx21

Protein Name

T-box 21

Synonyms

Tbet; Tblym; TBT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001484

InnateDB Gene

IDBG-210153 (Tbx21)

Protein Structure

UniProt Annotation

Function

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

T-cell specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	27 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009615	response to virus
GO:0030217	T cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050776	regulation of immune response
GO:0071310	cellular response to organic substance
GO:0072676	lymphocyte migration