InnateDB Protein
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IDBP-210180.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mapre1
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Protein Name
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microtubule-associated protein, RP/EB family, member 1
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Synonyms
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5530600P05Rik; AI462499; AI504412; AW260097; BIM1p; D2Ertd459e; Eb1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028981
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InnateDB Gene
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IDBG-210178 (Mapre1)
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Protein Structure
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Function |
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (By similarity). May play a role in cell migration. {ECO:0000250, ECO:0000269PubMed:15311282}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed within the midpiece of sperm tail (at protein level). {ECO:0000269PubMed:23055941}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
40 [view]
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Molecular Function |
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Biological Process |
GO:0007067
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mitotic nuclear division
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GO:0031115
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negative regulation of microtubule polymerization
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GO:0035372
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protein localization to microtubule
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GO:1903033
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positive regulation of microtubule plus-end binding
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Cellular Component |
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PDB ID |
MGI:891995
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InterPro |
IPR001715
Calponin homology domain
IPR004953
EB1, C-terminal
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PFAM |
PF00307
PF03271
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PRINTS |
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PIRSF |
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SMART |
SM00033
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TIGRFAMs |
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Modification |
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SwissProt |
Q61166
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PhosphoSite |
PhosphoSite-Q61166
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TrEMBL |
Q3U4H0
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UniProt Splice Variant |
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Entrez Gene |
13589
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UniGene |
Mm.470371
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RefSeq |
NP_031922
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MGI ID |
1V5K
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MGI Symbol |
Mapre1
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OMIM |
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CCDS |
CCDS16917
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HPRD |
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IMGT |
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EMBL |
AK154245
BC052405
BC064444
CH466551
U51196
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GenPept |
AAA96320
AAH52405
AAH64444
BAE32461
EDL06041
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