InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Socs7

Summary

InnateDB Protein

IDBP-210244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Socs7

Protein Name

suppressor of cytokine signaling 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040896

InnateDB Gene

IDBG-210242 (Socs7)

Protein Structure

UniProt Annotation

Function

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15242778}. Cell membrane {ECO:0000269PubMed:15242778}; Peripheral membrane protein {ECO:0000269PubMed:15242778}; Cytoplasmic side {ECO:0000269PubMed:15242778}. Nucleus {ECO:0000269PubMed:15242778}. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in brain and testis where it is expressed by spermatocytes and early spermatids. Also significantly expressed in spleen, skeletal muscle and kidney. {ECO:0000269PubMed:12052866, ECO:0000269PubMed:15494444, ECO:0000269PubMed:16127460}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008286	insulin receptor signaling pathway
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0045444	fat cell differentiation