Version 5.4
Mus musculus Protein: Rnf40
Summary
InnateDB Protein IDBP-210308.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf40
Protein Name ring finger protein 40
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033088
InnateDB Gene IDBG-210306 (Rnf40)
Protein Structure
UniProt Annotation
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0017075 syntaxin-1 binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010390 histone monoubiquitination
GO:0033523 histone H2B ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0033503 HULC complex
GO:0043005 neuron projection
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2142048
InterPro IPR001841 Zinc finger, RING-type
PFAM PF13639
PF14634
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U319
PhosphoSite PhosphoSite-Q3U319
TrEMBL
UniProt Splice Variant
Entrez Gene 233900
UniGene Mm.471330
RefSeq NP_758485
MGI ID
MGI Symbol Rnf40
OMIM
CCDS CCDS21871
HPRD
IMGT
EMBL AK042654 AK089805 AK129184 AK154982 AK171462 BC038348
GenPept AAH38348 BAC31322 BAC40966 BAC97994 BAE32971 BAE42468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca