Version 5.4
Mus musculus Protein: Psmb3
Summary
InnateDB Protein IDBP-210311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmb3
Protein Name proteasome (prosome, macropain) subunit, beta type 3
Synonyms AL033320; C10-II;
Species Mus musculus
Ensembl Protein ENSMUSP00000099436
InnateDB Gene IDBG-210309 (Psmb3)
Protein Structure
UniProt Annotation
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. {ECO:0000269PubMed:22341445}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0030163 protein catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005839 proteasome core complex
Protein Structure and Domains
PDB ID MGI:1347014
InterPro IPR001353 Proteasome, subunit alpha/beta
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF00227
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R1P1
PhosphoSite PhosphoSite-Q9R1P1
TrEMBL Q545G0
UniProt Splice Variant
Entrez Gene 26446
UniGene Mm.21874
RefSeq NP_036101
MGI ID 3UNH
MGI Symbol Psmb3
OMIM
CCDS CCDS25328
HPRD
IMGT
EMBL AF060092 AK002331 AK010488 AK153162 BC014783 BC098233 CH466556
GenPept AAD50537 AAH14783 AAH98233 BAB22017 BAB26979 BAE31772 EDL16092

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca