InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bckdk

Summary

InnateDB Protein

IDBP-210443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bckdk

Protein Name

branched chain ketoacid dehydrogenase kinase

Synonyms

AI327402;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070345

InnateDB Gene

IDBG-210441 (Bckdk)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0009083	branched-chain amino acid catabolic process
GO:0016310	phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex

Protein Structure and Domains

PDB ID

MGI:1276121

InterPro

IPR003594 Histidine kinase-like ATPase, ATP-binding domain
IPR004358 Signal transduction histidine kinase-related protein, C-terminal
IPR005467 Signal transduction histidine kinase, core
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal

PFAM

PF02518
PF13581
PF10436

PRINTS

PR00344

PIRSF

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt