InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kat8

Summary

InnateDB Protein

IDBP-210452.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kat8

Protein Name

MYST histone acetyltransferase 1

Synonyms

2010203C02Rik; 5830450F21Rik; D7Ertd629e; MOF; Myst1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033070

InnateDB Gene

IDBG-210450 (Kat8)

Protein Structure

UniProt Annotation

Function

Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016407	acetyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019899	enzyme binding
GO:0035064	methylated histone binding
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046872	metal ion binding
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016573	histone acetylation
GO:0030099	myeloid cell differentiation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0000776	kinetochore
GO:0005634	nucleus
GO:0031965	nuclear membrane
GO:0071339	MLL1 complex
GO:0072487	MSL complex

Protein Structure and Domains

PDB ID

MGI:1915023

InterPro

IPR000953 Chromo domain/shadow
IPR002717 MOZ/SAS-like protein
IPR016181 Acyl-CoA N-acyltransferase
IPR016197 Chromo domain-like
IPR025995 RNA binding activity-knot of a chromodomain

PFAM

PF01853
PF11717

PRINTS

PIRSF

SMART

SM00298

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D1P2