Version 5.4
Mus musculus Protein: Fbxl20
Summary
InnateDB Protein IDBP-210480.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl20
Protein Name F-box and leucine-rich repeat protein 20
Synonyms 2610511F20Rik; 4632423N09Rik; AI849362; AL117906; C86145; Fbl2; mKIAA4147; Scr;
Species Mus musculus
Ensembl Protein ENSMUSP00000099432
InnateDB Gene IDBG-210478 (Fbxl20)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Isoform 3 regulates neural transmission by binding and ubiquitinating RIMS1, a modulator of presynaptic plasticity. {ECO:0000269PubMed:17803915}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17803915}. Note=Isoform 3 is present at the presynaptic membrane.
Disease Associations
Tissue Specificity Highly expressed in brain. {ECO:0000269PubMed:17803915}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001662 behavioral fear response
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1919444
InterPro IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
SM00367
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CZV8
PhosphoSite PhosphoSite-Q9CZV8
TrEMBL A2A533
UniProt Splice Variant
Entrez Gene 72194
UniGene Mm.438264
RefSeq NP_082425
MGI ID
MGI Symbol Fbxl20
OMIM
CCDS CCDS25339
HPRD
IMGT
EMBL AK012109 AK036217 AK144786 AK220232 AL591205 AL591209 EF649694
GenPept ABU95014 BAB28039 BAC29349 BAD90157 BAE26066 CAM20406 CAM21260

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca