InnateDB Protein
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IDBP-210493.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif2s2
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Protein Name
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eukaryotic translation initiation factor 2, subunit 2 (beta)
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Synonyms
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2810026E11Rik; 38kDa; AA408636; AA571381; AA986487; AW822225; D2Ertd303e; EIF2; EIF2B;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000096777
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InnateDB Gene
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IDBG-210491 (Eif2s2)
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Protein Structure
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Function |
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
29 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914454
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InterPro |
IPR002735
Translation initiation factor IF2/IF5
IPR016189
Translation initiation factor IF2/IF5, N-terminal
IPR016190
Translation initiation factor IF2/IF5, zinc-binding
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PFAM |
PF01873
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PRINTS |
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PIRSF |
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SMART |
SM00653
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TIGRFAMs |
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Modification |
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SwissProt |
Q99L45
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PhosphoSite |
PhosphoSite-Q99L45
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TrEMBL |
Q3ULL5
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UniProt Splice Variant |
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Entrez Gene |
67204
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UniGene |
Mm.407258
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RefSeq |
NP_080306
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MGI ID |
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MGI Symbol |
Eif2s2
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OMIM |
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CCDS |
CCDS38292
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HPRD |
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IMGT |
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EMBL |
AK011503
AK012817
AK145401
AK145434
AK166862
AL929024
BC003848
BC113766
CH466551
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GenPept |
AAH03848
AAI13767
BAB27663
BAB28490
BAE26414
BAE26433
BAE39077
EDL06103
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