InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med1

Summary

InnateDB Protein

IDBP-210502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med1

Protein Name

mediator complex subunit 1

Synonyms

AI480703; CRSP210; DRIP205; l11Jus15; PBP; Pparbp; TRAP220;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090411

InnateDB Gene

IDBG-210500 (Med1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	26 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	107 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006590	thyroid hormone generation
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0007507	heart development
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0030224	monocyte differentiation
GO:0031100	organ regeneration
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0033598	mammary gland epithelial cell proliferation
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0035050	embryonic heart tube development
GO:0035116	embryonic hindlimb morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0043010	camera-type eye development
GO:0045444	fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048821	erythrocyte development
GO:0048822	enucleate erythrocyte development
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744	mammary gland branching involved in thelarche
GO:0060745	mammary gland branching involved in pregnancy
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
GO:0070318	positive regulation of G0 to G1 transition
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:2000347	positive regulation of hepatocyte proliferation

Cellular Component

GO:0005634	nucleus
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

MGI:1100846

InterPro

IPR019680 Mediator complex, subunit Med1, metazoa/fungi

PFAM

PF10744

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AQH6

UniProt Splice Variant

Entrez Gene

19014

UniGene

Mm.470405

RefSeq

NP_598788

MGI ID

MGI Symbol

Med1

OMIM

CCDS

HPRD

IMGT

EMBL

AL591205 CH466556

GenPept

EDL16118