Version 5.4
Mus musculus Protein: Med1
Summary
InnateDB Protein IDBP-210504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Med1
Protein Name mediator complex subunit 1
Synonyms AI480703; CRSP210; DRIP205; l11Jus15; PBP; Pparbp; TRAP220;
Species Mus musculus
Ensembl Protein ENSMUSP00000018304
InnateDB Gene IDBG-210500 (Med1)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. {ECO:0000269PubMed:10882104, ECO:0000269PubMed:11867769, ECO:0000269PubMed:12037571, ECO:0000269PubMed:14500757, ECO:0000269PubMed:14636573, ECO:0000269PubMed:15150259, ECO:0000269PubMed:15340084, ECO:0000269PubMed:16137621, ECO:0000269PubMed:17132730, ECO:0000269PubMed:9325263}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15150259}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed in the adult, with high levels of expression in the liver, lung, intestinal mucosa, kidney cortex, thymic cortex, splenic follicle and seminiferous epithelium in testis. Also expressed in the adult heart, brain, spleen and skeletal muscle. {ECO:0000269PubMed:14500757, ECO:0000269PubMed:9325263}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 26 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 107 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 core promoter binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 thyroid hormone receptor coactivator activity
GO:0031490 chromatin DNA binding
GO:0032403 protein complex binding
GO:0035257 nuclear hormone receptor binding
GO:0036033 mediator complex binding
GO:0042809 vitamin D receptor binding
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0050693 LBD domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0002088 lens development in camera-type eye
GO:0002154 thyroid hormone mediated signaling pathway
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003406 retinal pigment epithelium development
GO:0006355 regulation of transcription, DNA-templated
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006590 thyroid hormone generation
GO:0006702 androgen biosynthetic process
GO:0007275 multicellular organismal development
GO:0007420 brain development
GO:0007507 heart development
GO:0007595 lactation
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010839 negative regulation of keratinocyte proliferation
GO:0030216 keratinocyte differentiation
GO:0030224 monocyte differentiation
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0031100 organ regeneration
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0033598 mammary gland epithelial cell proliferation
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0035050 embryonic heart tube development
GO:0035116 embryonic hindlimb morphogenesis
GO:0035162 embryonic hemopoiesis
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035855 megakaryocyte development
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0045444 fat cell differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048821 erythrocyte development
GO:0048822 enucleate erythrocyte development
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744 mammary gland branching involved in thelarche
GO:0060745 mammary gland branching involved in pregnancy
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0070318 positive regulation of G0 to G1 transition
GO:0070371 ERK1 and ERK2 cascade
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0097067 cellular response to thyroid hormone stimulus
GO:2000273 positive regulation of receptor activity
GO:2000347 positive regulation of hepatocyte proliferation
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016592 mediator complex
GO:0032993 protein-DNA complex
Protein Structure and Domains
PDB ID MGI:1100846
InterPro IPR019680 Mediator complex, subunit Med1, metazoa/fungi
PFAM PF10744
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q925J9
PhosphoSite PhosphoSite-Q925J9
TrEMBL
UniProt Splice Variant
Entrez Gene 19014
UniGene Mm.470405
RefSeq NP_038662
MGI ID 1XDK
MGI Symbol Med1
OMIM
CCDS CCDS25341
HPRD
IMGT
EMBL AF000294 AF332073 AF332074 AK049203 AK054437 AK147199 AL591205 AY176046 BC021440 BC079636
GenPept AAC31118 AAH21440 AAH79636 AAK56101 AAK56102 AAN75014 BAC33607 BAC35779 BAE27757 CAM21264 CAM21266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca