InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim72

Summary

InnateDB Protein

IDBP-210522.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim72

Protein Name

tripartite motif-containing 72

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079832

InnateDB Gene

IDBG-210520 (Trim72)

Protein Structure

UniProt Annotation

Function

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles. {ECO:0000269PubMed:19029292, ECO:0000269PubMed:19043407, ECO:0000269PubMed:19202355, ECO:0000269PubMed:19380584}.

Subcellular Localization

Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.

Disease Associations

Tissue Specificity

Muscle-specific. Exclusively expressed in cardiac and skeletal muscle. {ECO:0000269PubMed:19043407}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0001778	plasma membrane repair
GO:0003012	muscle system process
GO:0006887	exocytosis
GO:0006900	membrane budding
GO:0007517	muscle organ development
GO:0051260	protein homooligomerization

Cellular Component

GO:0005622	intracellular
GO:0030659	cytoplasmic vesicle membrane
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

MGI:3612190

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt