Version 5.4
Mus musculus Protein: Trp53inp2
Summary
InnateDB Protein IDBP-210561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trp53inp2
Protein Name transformation related protein 53 inducible nuclear protein 2
Synonyms 1110029F20Rik; Tp53inp2;
Species Mus musculus
Ensembl Protein ENSMUSP00000037627
InnateDB Gene IDBG-210559 (Trp53inp2)
Protein Structure
UniProt Annotation
Function Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. {ECO:0000269PubMed:18030323}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0001649 osteoblast differentiation
GO:0006351 transcription, DNA-templated
GO:0010508 positive regulation of autophagy
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0016605 PML body
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:1915978
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CFU8
PhosphoSite PhosphoSite-Q8CFU8
TrEMBL A2ARD1
UniProt Splice Variant
Entrez Gene 68728
UniGene Mm.474909
RefSeq NP_835212
MGI ID
MGI Symbol Trp53inp2
OMIM
CCDS CCDS16947
HPRD
IMGT
EMBL AJ297793 AJ311669 AK146589 AK170132 AL845325 BC036958 BC043086
GenPept AAH36958 AAH43086 BAE27284 BAE41585 CAC82594 CAC84145 CAM21116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca